"We ourselves feel that what we are doing is just a drop in the ocean. But the ocean would be less because of that missing drop."

I am a PhD student in cancer immunotherapy at Guy´s Hospital (King´s College London, KCL) and Barts Cancer Institute (BCI). My doctoral research, led by Dr. Sophie Papa (KCL) and Jane Sosabowski (BCI), aims to increase the success of cancer immunotherapy for solid tumours by developing an absolute quantitation method for genetically modified T-cell-based therapies. I investigate chimeric antigen receptor (CAR) T-cell behaviour in pre-clinical models using dual isotope PET/SPECT/CT imaging. My research is kindly supported by the CRUK City of London Center.

I hold a BSc in Biotechnology from the University of Salamanca (Spain), having completed my final year at University of Melbourne (Australia) and an MRes in Molecular and Cellular BioSciences from Imperial College London. In the past, I have worked on different projects in neuroscience and synthetic biology. Before joining KCL, I worked with Dr. Karin Straathof at UCL Great Ormond Street Institute of Child Health in the development of T-cell based therapies for two childhood cancers i.e., neuroblastoma and DIPG. I also worked on the dissociation of fresh tumour samples to assess for candidate target antigen expression using scRNAseq.

I enjoy sharing my research not only with other researchers but also with members of the general public, so please do get in touch if you would like to know more.

Eva Bugallo Blanco

eva.bugallo_blanco@kcl.ac.uk
Research Oncology Department
King´s College London
Guy´s Hospital,Bermondsey Wing
Great Maze Pond
London, SE1 9RT
United Kingdom

Publications

Peer-reviewed articles

Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2
GPellizzari,O Martinez,S Crescioli,R Page [...],E Bugallo-Blanco, [...] SN Karagiannis

Journal for immunotherapy of cancer, 2021

Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients
S Abdul-Jawad, L Baù, T Alaguthurai, IDM Del Barrio, [...],E Bugallo-Blanco, [...] S Irshad

Cancer Cell,2 021

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
G Kildisiute, WM Kholosy, MD Young, K Roberts, [...],E Bugallo-Blanco, [...] K Straathof, S Behjati

Science Advances, 2021

Single cell derived mRNA signals across human kidney tumors .
Young D. M, Mitchell J T, Custers MC.A, Khanbirova E, Olver RW.T, Comitani F, Piapi A, Bugallo-Blanco E, Thevanesan C, Straahof K, Behjati S, et al.

Nature Communications, 2021

A dynamic COVID-19 immune signature includes associations with poor prognosis
AG Laing, A Lorenc, IDM Del Barrio, A Das, M Fish, [...],E Bugallo-Blanco, [...] AC Hayday

Nature medicine, 2020

A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis
AG Laing, A Lorenc, IDM Del Barrio, A Das, M Fish, [...],E Bugallo-Blanco, [...] AC Hayday

Medrxiv, 2020



Posters

Development of an absolute quantitation method for genetically modified cell therapy
European Association for Cancer Research meeting, Torino, 2023.
No more shots in the dark: development of an absolute quantitation method for genetically modified cell therapy
The 17th European Molecular Imaging Meeting, Thessaloniki, 2022.
No more shots in the dark: Imaging and quantifying CAR T-cells [PDF]
Poster Prize, 2021 CRUK City of London Center Symposium, London, March 2021.
Next generation T-cell immunotherpay in neuroblastoma
UCL Institute of Child Health, London, December 2018.

Talks

"No more shots in the dark: modeling CAR T cell traficking”, Annual metting from the International Society for Cell and Gene Therapy, Paris, May 2023 "No more shots in the dark: trackig and imaging CAR T-cells”, Annual CRUK City of London Center Symposium, Francis Crick Institute, London, February 2020 "Next generation GD2-targeted immunotherapeutics”, Bi-Annual Symposium Cancer, UCL Institute of Child Health, London, June 2018 "GMOs, superheroes or supervillains?”, FEBIotec, III Biotechnology Week, Salamanca, 2015. "Genes and inherited diseases”, FEBiotec, II Biotechnology Week, Salamanca, Spain, 2013

Press

Theses

Analysis of the hetero-hexamer HrpRS that regulates the Secretion System in Pseudomonas syringae pv. Tomato DC3000, Imperial College London,UK, September 2017. Role of GABAergic neurons in thermoregulation and sleep, Imperial College London, UK, June 2017. Characterization of recombinant proteins in mammalian cells, Imperial College London, UK, January 2017. Oligonucleotide RNA Targeting: A Novel Therapy for Treating Friedreich’s Ataxia, University of Melbourne, Australia, June 2016.