"We ourselves feel that what we are doing is just a drop in the ocean. But the ocean would be less because of that missing drop."
I am a PhD student in cancer immunotherapy at Guy´s Hospital (King´s College London, KCL) and Barts Cancer Institute (BCI). My doctoral research, led by Dr. Sophie Papa (KCL) and Jane Sosabowski (BCI), aims to increase the success of cancer immunotherapy for solid tumours by developing an absolute quantitation method for genetically modified T-cell-based therapies. I investigate chimeric antigen receptor (CAR) T-cell behaviour in pre-clinical models using dual isotope PET/SPECT/CT imaging. My research is kindly supported by the CRUK City of London Center.
I hold a BSc in Biotechnology from the University of Salamanca (Spain), having completed my final year at University of Melbourne (Australia) and an MRes in Molecular and Cellular BioSciences from Imperial College London. In the past, I have worked on different projects in neuroscience and synthetic biology. Before joining KCL, I worked with Dr. Karin Straathof at UCL Great Ormond Street Institute of Child Health in the development of T-cell based therapies for two childhood cancers i.e., neuroblastoma and DIPG. I also worked on the dissociation of fresh tumour samples to assess for candidate target antigen expression using scRNAseq.
I enjoy sharing my research not only with other researchers but also with members of the general public, so please do get in touch if you would like to know more.
Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2
GPellizzari,O Martinez,S Crescioli,R Page [...],E Bugallo-Blanco, [...] SN Karagiannis
Journal for immunotherapy of cancer, 2021
Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients
S Abdul-Jawad, L Baù, T Alaguthurai, IDM Del Barrio, [...],E Bugallo-Blanco, [...] S IrshadCancer Cell,2 021
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
G Kildisiute, WM Kholosy, MD Young, K Roberts, [...],E Bugallo-Blanco, [...] K Straathof, S BehjatiScience Advances, 2021
Single cell derived mRNA signals across human kidney tumors .
Young D. M, Mitchell J T, Custers MC.A, Khanbirova E, Olver RW.T, Comitani F, Piapi A, Bugallo-Blanco E, Thevanesan C, Straahof K, Behjati S, et al.Nature Communications, 2021
A dynamic COVID-19 immune signature includes associations with poor prognosis
AG Laing, A Lorenc, IDM Del Barrio, A Das, M Fish, [...],E Bugallo-Blanco, [...] AC Hayday
Nature medicine, 2020
A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis
AG Laing, A Lorenc, IDM Del Barrio, A Das, M Fish, [...],E Bugallo-Blanco, [...] AC HaydayMedrxiv, 2020
Development of an absolute quantitation method for genetically modified cell therapy
European Association for Cancer Research meeting, Torino, 2023.
No more shots in the dark: development of an absolute quantitation method for genetically modified cell therapy
The 17th European Molecular Imaging Meeting, Thessaloniki, 2022.
No more shots in the dark: Imaging and quantifying CAR T-cells [PDF]
Poster Prize, 2021 CRUK City of London Center Symposium, London, March 2021.
Next generation T-cell immunotherpay in neuroblastoma
UCL Institute of Child Health, London, December 2018.